Source:http://linkedlifedata.com/resource/chebi/id/CHEBI:64061
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration." []
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| skos:inScheme | |
| skos:prefLabel |
CGP 78608
|
| skos:altLabel |
[(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid
|
| skos:notation |
CiteXplore:15223384 "PubMed citation",
CiteXplore:17405869 "PubMed citation",
CiteXplore:19394327 "PubMed citation",
Patent:US6117873 "Patent",
Reaxys:8227979 "Reaxys Registry Number"
|
| skos:broader | |
| skos:relatedSynonym |
C11H13BrN3O5P,
C[C@@H](NCc1cc(Br)cc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O,
InChI=1S/C11H13BrN3O5P/c1-5(21(18,19)20)13-4-6-2-7(12)3-8-9(6)15-11(17)10(16)14-8/h2-3,5,13H,4H2,1H3,(H,14,16)(H,15,17)(H2,18,19,20)/t5-/m0/s1,
InChIKey=DPFHVUSPVHRVFL-YFKPBYRVSA-N
|