http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and transfected cells confirm that 14-3-3 interacts with dSlo via Slob. All three proteins are colocalized presynaptically at Drosophila neuromuscular junctions. Two serine residues in Slob are required for 14-3-3 binding, and the binding is dynamically regulated in Drosophila by calcium/calmodulin-dependent kinase II (CaMKII) phosphorylation. 14-3-3 coexpression dramatically alters dSlo channel properties when wild-type Slob is present but not when a double serine mutant Slob that is incapable of binding 14-3-3 is present. The results provide evidence for a dSlo/Slob/14-3-3 regulatory protein complex. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | Neuron | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Zhou Y. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Levitan I.B. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Dagan D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Jaramillo A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Griffith L.C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Schopperle W.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Murrey H. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 1999 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 809-818 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 22 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1016/S0896-6273(00)80739-4 | lld:uniprot |
uniprot-protein:P29310 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
uniprot-protein:Q8IPH9 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
uniprot-protein:Q03720 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |