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skos:definition |
MSH: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.,CSP: NO; originally found as an intercellular messenger molecule in vascular smooth muscle, where it has a relaxant, vasodilatory effect; formed by oxidation of arginine with citrulline as side product; in nervous tissue, may be part of glutamate-calcium-cGMP signal transduction system.,CHV: name of an inorganic chemical,CHV: name of an inorganic chemical,CHV: name of an inorganic chemical,CHV: name of an inorganic chemical,NCI: An unstable free-radical gas which reacts rapidly with oxygen to form nitrogen
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