Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa (By similarity).
Source:http://purl.uniprot.org/SHA-384/E2FDAFF23B62C4456567E271FE94AFA7DC848DBE9AB48CF938825CE57DDDAEA02E29333BECD8F72968D56131A3769B92
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