S-adenosyl-L-methionine + adenosine(4) in tRNA(His) = S-adenosyl-L-homocysteine + 2'-O-methyladenosine(4) in tRNA(His).
Source:http://purl.uniprot.org/SHA-384/B51E95B67CFB63FBF1602E30088EB3D235D1A5756A798C336A010942879D3705D1C60833E65DA4CAF363AC107108BD97
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