Homooligomer, may form homodimer. Interacts with p6-gag region of the Pr55 Gag precursor protein through a (Leu-X-X)4 motif near the C terminus of the P6gag protein. Interacts with host SLC25A4/ANT1, SLC25A5/ANT2, SLC25A6/ANT3, SP1, CDC25C, RAD23A/HHR23A, COPS6/HVIP, TFIIB, UNG, SF3B2/SAP145, KPNA1 and KPNA2. Interacts with host VPRPB/DCAF-1, leading to change substrate specificity of the CUL4A-DDB1 E3 ligase complex and arrest the cell cycle in G2 phase. Interacts with ANKHD1 (By similarity).