Inhibition of host PKR by virus

Viral protein involved in the evasion of the interferon pathway by inhibiting the interferon induced PKR/EIF2AK2 protein. During viral replication of RNA viruses, dsRNA is produced leading to the activation of the PKR/EIF2AK2 kinase. Once activated, PKR/EIF2AK2 autophosphorylates and catalyzes the phosphorylation of many substrates including the translation initiation factor EIF2S1, leading to the inhibition of the initiation of protein synthesis. Several viral proteins prevent PKR/EIF2AK2 activation by direct interaction while others target PKR/EIF2AK2 to degradation.

Source:http://purl.uniprot.org/keywords/1102

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Subject	Predicate
http://purl.uniprot.org/keywords/1114	skos:narrower
uniprot-protein:P03244, uniprot-protein:Q1HVH2, uniprot-protein:Q04360, uniprot-protein:O42053, uniprot-protein:P03496, uniprot-protein:Q6XTC2, uniprot-protein:Q9Q0L6, uniprot-protein:P03502, uniprot-protein:P03126, uniprot-protein:P04487, uniprot-protein:P89479, uniprot-protein:P32224, uniprot-protein:P21605, uniprot-protein:P33863, uniprot-protein:P18378, uniprot-protein:Q6SW04, uniprot-protein:Q6SVX2, uniprot-protein:P21081, uniprot-protein:P35943, uniprot-protein:P22677, uniprot-protein:Q65708, uniprot-protein:P24566, uniprot-protein:P03418, uniprot-protein:P26589, uniprot-protein:Q83957, uniprot-protein:P03527, uniprot-protein:P30211, uniprot-protein:P07939, uniprot-protein:P09715, uniprot-protein:P09695, uniprot-protein:Q3KSU1, uniprot-protein:P69278, uniprot-protein:Q0PDM0, uniprot-protein:Q8QPI8, uniprot-protein:Q289M1, uniprot-protein:Q809X6, uniprot-protein:Q809Y0, uniprot-protein:Q809X8, uniprot-protein:Q809X2, uniprot-protein:P36349, uniprot-protein:Q6DP70, uniprot-protein:Q6DP68, uniprot-protein:Q6DP66, uniprot-protein:Q6DP64, uniprot-protein:Q6J871, uniprot-protein:Q6DP62, uniprot-protein:Q6J880, uniprot-protein:Q6DP28, uniprot-protein:B4URE2, uniprot-protein:A8C8K0, uniprot-protein:Q99AU3, uniprot-protein:P18295, uniprot-protein:Q82506, uniprot-protein:P03500, uniprot-protein:A4GCM5, uniprot-protein:A4GCJ2, uniprot-protein:Q0HD54, uniprot-protein:A4GCL4, uniprot-protein:A4U6V8, uniprot-protein:P03499, uniprot-protein:P30909, uniprot-protein:Q0A442, uniprot-protein:P69279, uniprot-protein:A4U7B2, uniprot-protein:P17042, uniprot-protein:A4K149, uniprot-protein:Q20NB9, uniprot-protein:P08272, uniprot-protein:O92551, uniprot-protein:Q1K9P7, uniprot-protein:P69272, uniprot-protein:P69273, uniprot-protein:P69274, uniprot-protein:Q6XTK0, uniprot-protein:Q0A2H0, uniprot-protein:P21431, uniprot-protein:O92564, uniprot-protein:P30911, uniprot-protein:O41647, uniprot-protein:Q3SBF0, uniprot-protein:Q6XTD8, uniprot-protein:P69277, uniprot-protein:Q0A462, uniprot-protein:Q91MA0, uniprot-protein:Q6XSW4, uniprot-protein:Q6XSV4, uniprot-protein:Q3YPY9, uniprot-protein:P08276, uniprot-protein:P03495, uniprot-protein:Q463W9, uniprot-protein:Q2ICQ4, uniprot-protein:Q67256, uniprot-protein:P30912, uniprot-protein:O09687, uniprot-protein:Q1PUD3, uniprot-protein:Q30NP5, uniprot-protein:P69252, uniprot-protein:P69270, uniprot-protein:P13137	uniprot:classifiedWith

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