N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule.
Source:http://purl.uniprot.org/SHA-384/B7F8027DA085F5CBCE142AD700E89ECFA1B927183D8EB05AFADE5DA90C5E99E74664139EFCB6BC25ABC491E2E34C6074
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