In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane (By similarity).
Source:http://purl.uniprot.org/SHA-384/50B6508CAE67FA6CB7106803F38EE3F1474D68595BE7421792E13205630CAB31C838AEB68B20440E34B4D9BA0F431F5A
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