42D6FC30CFF0D147EE6BE19D5EA28918A5D6073E8831A4C352E5269F9F32AE6D18E4790A9954E20194B5E743DEFDDA40

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Source:http://purl.uniprot.org/SHA-384/42D6FC30CFF0D147EE6BE19D5EA28918A5D6073E8831A4C352E5269F9F32AE6D18E4790A9954E20194B5E743DEFDDA40

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SubjectPredicate
uniprot:annotation