Linked Life Data

19507B3C415E1320FC96410CF0BD4C3A9608CD7C07E23C58149FD691F95D79B500371D014D9AC133D1C0F7B26C9F9683

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike. There seems to be as few as 10 spikes on the average virion. Surface protein gp120 interacts with human CD4, CCR5 and CXCR4, to form a P4HB/PDI-CD4-CXCR4-gp120 complex. Gp120 also interacts with the C-type lectins CD209/DC-SIGN and CLEC4M/DC-SIGNR (collectively referred to as DC-SIGN(R)). Gp120 and gp41 interact with GalCer. Gp120 interacts with human ITGA4/ITGB7 complex; on CD4+ T-cells, this interaction results in rapid activation of integrin ITGAL/LFA-1, which facilitate efficient cell-to-cell spreading of HIV-1. Gp120 interacts with cell-associated heparan sulfate; this interaction increases virus infectivity on permissive cells and may be involved in infection of CD4- cells (By similarity).

Source:http://purl.uniprot.org/SHA-384/19507B3C415E1320FC96410CF0BD4C3A9608CD7C07E23C58149FD691F95D79B500371D014D9AC133D1C0F7B26C9F9683

Statements in which the resource exists as a object.
SubjectPredicate
uniprot-protein:O12164, uniprot-protein:O41803, uniprot-protein:O70902, uniprot-protein:O89292, uniprot-protein:O91086, uniprot-protein:P03375, uniprot-protein:P03377, uniprot-protein:P03378, uniprot-protein:P04579, uniprot-protein:P04580, uniprot-protein:P04581, uniprot-protein:P04582, uniprot-protein:P04583, uniprot-protein:P04624, uniprot-protein:P05877, uniprot-protein:P05878, uniprot-protein:P05879, uniprot-protein:P05880, uniprot-protein:P05881, uniprot-protein:P05882, uniprot-protein:P12487, uniprot-protein:P12488, uniprot-protein:P12489, uniprot-protein:P18799, uniprot-protein:P19549, uniprot-protein:P19550, uniprot-protein:P19551, uniprot-protein:P20871, uniprot-protein:P20888, uniprot-protein:P31819, uniprot-protein:P31872, uniprot-protein:P35961, uniprot-protein:Q70626, uniprot-protein:Q73372, uniprot-protein:Q75008, uniprot-protein:Q77377, uniprot-protein:Q79670, uniprot-protein:Q9IDV2, uniprot-protein:Q9Q714, uniprot-protein:Q9QBY2, uniprot-protein:Q9QBZ0, uniprot-protein:Q9QBZ4, uniprot-protein:Q9QBZ8, uniprot-protein:Q9QSQ7, uniprot-protein:Q9WC60, uniprot-protein:Q9WC69
uniprot:annotation
rdf:subject