Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons.
Source:http://purl.uniprot.org/SHA-384/141408B36129975D783E53A2C81A46CB528ABD7C5EB0BCDC9B53C57A12E6FBBAB5F3442D3722EDF4A704ADF54A76E2DF
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