| http://www.reactome.org/bio... | rdf:type | biopax3:BiochemicalReaction | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:comment | Authored: Garapati, P V, 2009-02-24 10:31:15 | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:comment | Edited: Garapati, P V, 2009-02-24 10:58:20 | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:comment | Reviewed: Maness, PF, Walmod, PS, 2009--0-5- | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:comment | FGFR is one of the heterophilic interactors of NCAM. The FG loop region of the second Fn3 module of NCAM binds to Ig domains 2 and 3 of FGFR. The FGFR binding site to NCAM overlaps with the site of NCAM-ATP interaction, and ATP is capable of disrupting NCAM-FGFR binding and signaling. <br>The interaction of NCAM activates FGFR and NCAM might merely mimic FGF's in FGFR stimulation, but there is a difference in the activation pattern induced by NCAM and FGF-2. NCAM activated FGFR stimulates neurite outgrowth by stimulating PLCgamma and DAG lipase leading to generation of arachidonic acid. | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | urn:biopax:UnificationXref:... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | urn:biopax:UnificationXref:... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:dataSource | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:dataSource | urn:biopax:Provenance:react... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:displayName | NCAM1 binds FGFR-1 | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:left | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:left | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:right | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:stepProcess | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:pathwayComponent | http://www.reactome.org/bio... | lld:biopax3 |
