| http://www.reactome.org/bio... | rdf:type | biopax3:Control | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:controlType | INHIBITION | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:controlled | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:comment | LGP2 acts as a natural negative regulator of dsRNA signaling. Several mechanisms may account for the LGP2 inhibitory effects. As a homolog of RIG-I, one attractive model is that LGP2 can sequester RNA ligands from recognition by RIG-I/MDA5. LGP2 has also been demonstrated to associate with RIG-I to inhibit its auto-oligomerizaton via the LGP2 C-terminal region comparable to the RIG-I repressor domain. In this model, dimerization of RIG-I by viral RNA, proposed to be an active form of RIG-I, is replaced by a RIG-I:LGP2 hetero-oligomer. | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | urn:biopax:UnificationXref:... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | http://identifiers.org/pubm... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:xref | urn:biopax:UnificationXref:... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:controller | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:dataSource | urn:biopax:Provenance:react... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:dataSource | http://www.reactome.org/bio... | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:displayName | 'LGP2 [cytosol]' negatively regulates 'dsRNA binds to RIG-I' | lld:biopax3 |
| http://www.reactome.org/bio... | biopax3:stepProcess | http://www.reactome.org/bio... | lld:biopax3 |
