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http://www.reactome.org/bio...biopax3:commentAuthored: May, B, 2009-07-22lld:biopax3
http://www.reactome.org/bio...biopax3:commentReviewed: Wilusz, J, 2009-09-17lld:biopax3
http://www.reactome.org/bio...biopax3:commentEdited: May, B, 2009-07-22lld:biopax3
http://www.reactome.org/bio...biopax3:commentThe PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.lld:biopax3
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