| http://purl.uniprot.org/enz... | rdf:type | uniprot:Enzyme | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | Found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | The enzyme, which is activated upon binding molecular oxygen, can catalyze both a monophenolase reaction cycle or a diphenolase reaction cycle. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an O-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an O-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | The second reaction is identical to that catalyzed by the related enzyme catechol oxidase (EC 1.10.3.1). | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:comment | However, the latter can not catalyze the hydroxylation or monooxygenation of monophenols. | lld:uniprot |
| http://purl.uniprot.org/enz... | rdfs:subClassOf | http://purl.uniprot.org/enz... | lld:uniprot |
| http://purl.uniprot.org/enz... | skos:broaderTransitive | http://purl.uniprot.org/enz... | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Tyrosinase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Monophenol monooxygenase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Cresolase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Monophenol oxidase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | N-acetyl-6-hydroxytryptophan oxidase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Phenolase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:name | Tyrosine-dopa oxidase | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:replaces | http://purl.uniprot.org/enz... | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:activity | (1) 2 L-dopa + O(2) = 2 dopaquinone + 2 H(2)O. | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:activity | (2) L-tyrosine + O(2) = dopaquinone + H(2)O. | lld:uniprot |
| http://purl.uniprot.org/enz... | uniprot:cofactor | Copper | lld:uniprot |
| http://purl.uniprot.org/enz... | skos:narrowerTransitive | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P14679 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P00440 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55033 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9BDE0 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q04604 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55025 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9V521 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8MIU0 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P54834 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9MYI7 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55026 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q27451 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q27452 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8I1F6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9W1V6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8J130 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q00234 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55024 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P11344 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q4WFT7 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B0DNR7 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B0DMA1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B0DMX0 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:C5PBC3 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A2QYL5 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A2QUC2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q49QX8 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q49I39 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q7K2W6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q49I38 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:E0W2W9 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:E0VUB6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:E0VX48 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A7LK11 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B7GA89 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:G0K0P4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B5SDW9 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:F6ECJ1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q093B2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B7JU04 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q92LD3 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A9G933 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q3JKD8 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D5DHA8 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q74NN3 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8KIL0 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q39ND4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B2J558 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B2IXG2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:F8B1J1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8Y2J8 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q82V60 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D5UDJ1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A6UM82 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A6UMX4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q0RT95 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q7NT03 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D5DZK6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q2T7K1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q8AYA1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q08410 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:O44249 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P85046 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q25519 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q64ID7 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GLU9 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GLV0 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GLV2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GLV1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GU90 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GU89 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q27598 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B5S824 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D2SMN2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:G4LWK1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q287T6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q5VM57 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:B9VNV4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q84YI1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q84YH9 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D7FJB5 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P33180 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A7WPD2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q86RQ6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:C6K2H4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D2KBI1 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:A8JKF6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:G3ESX4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:E0AEY7 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D6QZJ9 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P07524 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P06845 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55023 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:P55022 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:D3CRL8 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q66NX4 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q66NX3 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q5ENY2 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
| uniprot-protein:Q9GVA6 | uniprot:enzyme | http://purl.uniprot.org/enz... | lld:uniprot |
