Linked Life Data

FEBS Lett.

Ectatomin (Ea) is a newly isolated main toxic component of Ectatomma tuberculatum ant venom. Structural and electrophysiological studies were performed with purified Ea. The protein consists of two homologous polypeptide chains (37 and 34 residues) and forms a four alpha-helix bundle in aqueous solution. On insertion into artificial bilayer membranes, two Ea molecules form an ion pore. Our results suggest that the 'inside-out' mechanism of pore formation requires a significant movement of Ea helical parts. The pore formation in the cell membrane might well explain the toxic activity of Ea, not excluding at the same time its intracellular activities.

Source:http://purl.uniprot.org/citations/8033986

Statements in which the resource exists.
SubjectPredicateObjectContext
http://purl.uniprot.org/cit...rdf:typeuniprot:Journal_Citationlld:uniprot
http://purl.uniprot.org/cit...rdfs:commentEctatomin (Ea) is a newly isolated main toxic component of Ectatomma tuberculatum ant venom. Structural and electrophysiological studies were performed with purified Ea. The protein consists of two homologous polypeptide chains (37 and 34 residues) and forms a four alpha-helix bundle in aqueous solution. On insertion into artificial bilayer membranes, two Ea molecules form an ion pore. Our results suggest that the 'inside-out' mechanism of pore formation requires a significant movement of Ea helical parts. The pore formation in the cell membrane might well explain the toxic activity of Ea, not excluding at the same time its intracellular activities.lld:uniprot
http://purl.uniprot.org/cit...skos:exactMatchhttp://purl.uniprot.org/med...lld:uniprot
http://purl.uniprot.org/cit...skos:exactMatchhttp://purl.uniprot.org/pub...lld:uniprot
http://purl.uniprot.org/cit...uniprot:nameFEBS Lett.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorArseniev A.S.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorNolde D.E.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorGrishin E.V.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorPluzhnikov K.A.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorSukhanov S.V.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorSobol A.G.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorTorgov M.Y.lld:uniprot
http://purl.uniprot.org/cit...uniprot:date1994lld:uniprot
http://purl.uniprot.org/cit...uniprot:pages112-116lld:uniprot
http://purl.uniprot.org/cit...uniprot:titleToxic principle of selva ant venom is a pore-forming protein transformer.lld:uniprot
http://purl.uniprot.org/cit...uniprot:volume347lld:uniprot
http://purl.uniprot.org/cit...dc-term:identifierdoi:10.1016/0014-5793(94)00518-4lld:uniprot
uniprot-protein:P49343uniprot:citationhttp://purl.uniprot.org/cit...lld:uniprot
uniprot-protein:P49344uniprot:citationhttp://purl.uniprot.org/cit...lld:uniprot
http://linkedlifedata.com/r...rdf:objecthttp://purl.uniprot.org/cit...lld:uniprot
http://linkedlifedata.com/r...rdf:objecthttp://purl.uniprot.org/cit...lld:uniprot