http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER membrane is not well understood. We have investigated the functional organization of the mammalian ERAD system using a systems-level strategy that integrates proteomics, functional genomics and the transcriptional response to ER stress. This analysis supports an adaptive organization for the mammalian ERAD machinery and reveals a number of metazoan-specific genes not previously linked to ERAD. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | Nat. Cell Biol. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Harper J.W. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kopito R.R. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Sowa M.E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Bennett E.J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Christianson J.C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Richter C.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Olzmann J.A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Shaler T.A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tyler R.E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Greenblatt E.J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2012 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 93-105 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | Defining human ERAD networks through an integrative mapping strategy. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 14 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1038/ncb2383 | lld:uniprot |
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