Arch. Virol.

Lactobacillus delbrueckii phages are a great source of genetic diversity. Here, the genome sequences of Lb. delbrueckii phages LL-Ku, c5 and JCL1032 were analyzed in detail, and the genetic diversity of Lb. delbrueckii phages belonging to different taxonomic groups was explored. The lytic isometric group b phages LL-Ku (31,080 bp) and c5 (31,841 bp) showed a minimum nucleotide sequence identity of 90% over about three-fourths of their genomes. The genomic locations of their lysis modules were unique, and the genomes featured several putative overlapping transcription units of genes. LL-Ku and c5 virions displayed peptidoglycan hydrolytic activity associated with a ~36-kDa protein similar in size to the endolysin. Unexpectedly, the 49,433-bp genome of the prolate phage JCL1032 (temperate, group c) revealed a conserved gene order within its structural genes. Lb. delbrueckii phages representing groups a (a phage LL-H), b and c possessed only limited protein sequence homology. Genomic comparison of LL-Ku and c5 suggested that diversification of Lb. delbrueckii phages is mainly due to insertions, deletions and recombination. For the first time, the complete genome sequences of group b and c Lb. delbrueckii phages are reported.

Source:http://purl.uniprot.org/citations/21465086

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http://purl.uniprot.org/cit...rdfs:commentLactobacillus delbrueckii phages are a great source of genetic diversity. Here, the genome sequences of Lb. delbrueckii phages LL-Ku, c5 and JCL1032 were analyzed in detail, and the genetic diversity of Lb. delbrueckii phages belonging to different taxonomic groups was explored. The lytic isometric group b phages LL-Ku (31,080 bp) and c5 (31,841 bp) showed a minimum nucleotide sequence identity of 90% over about three-fourths of their genomes. The genomic locations of their lysis modules were unique, and the genomes featured several putative overlapping transcription units of genes. LL-Ku and c5 virions displayed peptidoglycan hydrolytic activity associated with a ~36-kDa protein similar in size to the endolysin. Unexpectedly, the 49,433-bp genome of the prolate phage JCL1032 (temperate, group c) revealed a conserved gene order within its structural genes. Lb. delbrueckii phages representing groups a (a phage LL-H), b and c possessed only limited protein sequence homology. Genomic comparison of LL-Ku and c5 suggested that diversification of Lb. delbrueckii phages is mainly due to insertions, deletions and recombination. For the first time, the complete genome sequences of group b and c Lb. delbrueckii phages are reported.lld:uniprot
http://purl.uniprot.org/cit...skos:exactMatchhttp://purl.uniprot.org/pub...lld:uniprot
http://purl.uniprot.org/cit...uniprot:nameArch. Virol.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorAlatossava T.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorForsman P.lld:uniprot
http://purl.uniprot.org/cit...uniprot:authorRiipinen K.A.lld:uniprot
http://purl.uniprot.org/cit...uniprot:date2011lld:uniprot
http://purl.uniprot.org/cit...uniprot:pages1217-1233lld:uniprot
http://purl.uniprot.org/cit...uniprot:titleThe genomes and comparative genomics of Lactobacillus delbrueckii phages.lld:uniprot
http://purl.uniprot.org/cit...uniprot:volume156lld:uniprot
http://purl.uniprot.org/cit...dc-term:identifierdoi:10.1007/s00705-011-0980-5lld:uniprot
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