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http://purl.uniprot.org/cit... | rdfs:comment | The multimerization/self-interaction of viral proteins is an important step in the process of viral assembly and maturation. Our previous study indicated that the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid protein forms self-multimers through a serine-arginine (SR)-rich motif (SSRSSSRSRGNSR) by using a mammalian two-hybrid system. To determine the biological relevance of this motif, we constructed a SARS-CoV reverse genetic construct by using a bacterial artificial chromosome (BAC)-based vector controlled by a T7 promoter; and subsequently deleted the SR-rich motif from the N gene. The mutated infectious clone showed reduced level of genome transcription and significantly reduced levels of the infectious virions. These results strongly suggest that the SR-rich motif is critical for effective virus replication. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | Can. J. Microbiol. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Li X. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Cao J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | He R. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Cutts T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Andonov A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Van Domselaar G. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tylor S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Grudesky E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2009 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 254-260 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 55 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1139/W08-139 | lld:uniprot |
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