http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | J. Cell Biol. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Jacquier A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Fromont-Racine M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rain J.-C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Decourty L. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Saveanu C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lebreton A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2006 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 349-360 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 173 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1083/jcb.200510080 | lld:uniprot |
uniprot-protein:P47019 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
uniprot-protein:P38344 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
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http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |