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http://purl.uniprot.org/cit... | rdfs:comment | Most of the >50,000 different pharmacologically active peptides in Conus venoms belong to a small number of gene superfamilies. In this work, the M-conotoxin superfamily is defined using both biochemical and molecular criteria. Novel excitatory peptides purified from the venoms of the molluscivorous species Conus textile and Conus marmoreus all have a characteristic pattern of Cys residues previously found in the mu-, kappaM-, and psi-conotoxins (CC-C-C-CC). The new peptides are smaller (12-19 amino acids) than the mu-, kappaM-, and psi-conotoxins (22-24 amino acids). One peptide, mr3a, was chemically synthesized in a biologically active form. Analysis of the disulfide bridges of a natural peptide tx3c from C. textile and synthetic peptide mr3a from C. marmoreus showed a novel pattern of disulfide connectivity, different from that previously established for the mu- and psi-conotoxins. Thus, these peptides belong to a new group of structurally and pharmacologically distinct conotoxins that are particularly prominent in the venoms of mollusc-hunting Conus species. Analysis of cDNA clones encoding the novel peptides as well as those encoding mu-, kappaM-, and psi-conotoxins revealed highly conserved amino acid residues in the precursor sequences; this conservation in both amino acid sequence and in the Cys pattern defines a gene superfamily, designated the M-conotoxin superfamily. The peptides characterized can be provisionally assigned to four distinct groups within the M-superfamily based on sequence similarity within and divergence between each group. A notable feature of the superfamily is that two distinct structural frameworks have been generated by changing the disulfide connectivity on an otherwise conserved Cys pattern. | lld:uniprot |
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http://purl.uniprot.org/cit... | uniprot:name | Biochemistry | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Li W. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Hillyard D.R. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | McIntosh J.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Cruz L.J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Olivera B.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gray W.R. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rivier J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Corpuz G.P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Walker C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Garrett J.E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Jimenez E.C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Watkins M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Jacobsen R.B. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Colledge C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | McDougal O. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2005 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 8176-8186 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 44 | lld:uniprot |
http://purl.uniprot.org/cit... | dc-term:identifier | doi:10.1021/bi047541b | lld:uniprot |
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