http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.8 million base pairs of highly accurate finished sequence representing 99.9% of the euchromatin portion of the chromosome. Manual curation of gene loci reveals 1,461 protein-coding genes and 321 pseudogenes. Among these are genes directly implicated in mendelian disorders, including familial hypercholesterolaemia and insulin-resistant diabetes. Nearly one-quarter of these genes belong to tandemly arranged families, encompassing more than 25% of the chromosome. Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu. | lld:uniprot |
http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:name | Nature | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Wagner M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gordon D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Hawkins T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tsai M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lamerdin J.E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Olsen A.S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Carrano A.V. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Huang W. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Wu K. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Yang J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Altherr M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Garcia C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Larionov V. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kobayashi A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Ramirez L. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gomez M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gonzales E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Nelson K. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rubin E.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Myers R.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Medina C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Smith D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Leem S.-H. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rodriguez A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Stubbs L. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lopez F. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Christensen M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rogers S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Black S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Morgan J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Richardson P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Terry A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Solovyev V. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Eichler E.E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Martinez D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Xie G. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Pennacchio L.A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Branscomb E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Detter J.C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | DeJong P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Ashworth L. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Gordon L.A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Flowers D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lucas S.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Chan Y.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Nolan M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Grimwood J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Furey T.S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Vo N. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Pollard M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Schmutz J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Dickson M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lou Y. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Georgescu A.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Jett J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Salazar A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Dehal P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rash S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Predki P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | She X. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Couronne O. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Dubchak I. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Ho I. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Glavina T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Rokhsar D.S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Ovcharenko I. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Malfatti S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Popkie A.P. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Quan G. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Wheeler J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Hellsten U. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Goodstein D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tran-Gyamfi M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Aerts A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Bajorek E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Caenepeel S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Caoile C. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Cleland C.A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Copeland A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Dalin E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Denys M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Escobar J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Fotopulos D. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Groza M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Hammon N. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Haydu L. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Israni S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kadner K. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kimball H. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Lowry S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | McCready P.M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Pitluck S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Retterer J. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Salamov A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Slezak T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Thayer N. | lld:uniprot |