uvi31+ is a sequence homolog of Escherichia coli bolA gene in Schizosaccharomyces pombe, identified as a UV-inducible gene. Here, the cellular function of uvi31+ was investigated by null mutant analysis. Deletion of uvi31+ led to a delayed germination of spore and defects in subsequent cell division. However, the uvi31 mutant cell proliferated faster with smaller cell size than the wild-type cell during vegetative growth. In addition, the uvi31 mutant was sensitive to UV-light. It showed a normal cell cycle delay after UV-irradiation but displayed aberrant septum formation and defective cytokinesis when released from the UV damage checkpoint. These results suggest that uvi31+ may be involved in control of cell division, especially during the resumption from cell cycle arrest.
| Subject | Predicate | Object | Context |
|---|---|---|---|
| http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
| http://purl.uniprot.org/cit... | rdfs:comment | uvi31+ is a sequence homolog of Escherichia coli bolA gene in Schizosaccharomyces pombe, identified as a UV-inducible gene. Here, the cellular function of uvi31+ was investigated by null mutant analysis. Deletion of uvi31+ led to a delayed germination of spore and defects in subsequent cell division. However, the uvi31 mutant cell proliferated faster with smaller cell size than the wild-type cell during vegetative growth. In addition, the uvi31 mutant was sensitive to UV-light. It showed a normal cell cycle delay after UV-irradiation but displayed aberrant septum formation and defective cytokinesis when released from the UV damage checkpoint. These results suggest that uvi31+ may be involved in control of cell division, especially during the resumption from cell cycle arrest. | lld:uniprot |
| http://purl.uniprot.org/cit... | skos:exactMatch | http://purl.uniprot.org/pub... | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:name | Mol. Cells | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:author | Kim H.S. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:author | Kim M.J. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:author | Lee J.K. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:author | Park S.D. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:author | Lee C.B. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:date | 2002 | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:pages | 425-430 | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:title | Regulation of septation and cytokinesis during resumption of cell division requires uvi31+, a UV-inducible gene of fission yeast. | lld:uniprot |
| http://purl.uniprot.org/cit... | uniprot:volume | 14 | lld:uniprot |
| uniprot-protein:Q12238 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
| http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
| http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |