http://purl.uniprot.org/cit... | rdf:type | uniprot:Journal_Citation | lld:uniprot |
http://purl.uniprot.org/cit... | rdfs:comment | Antigen (Ag) immunization induces formation of the germinal center (GC), with large, rapidly proliferating centroblasts in the dark zone, and small, nondividing centrocytes in the light zone. We identified a novel nuclear protein, GANP, that is up-regulated in centrocytes. We found that GANP was up-regulated in GC B cells of Peyer's patches in normal mice and in spleens from Ag-immunized mice. GANP-positive cells appeared in the light zone of the GC, with coexpression of the peanut agglutinin (PNA) (PNA)-positive B220-positive phenotype. The expression of GANP was strikingly correlated with GC formation because Bcl6-deficient mice did not show the up-regulation of GANP. GANP-positive cells were mostly surrounded by follicular dendritic cells. Stimulation with anti-micro and anti-CD40 induced up-regulation of ganp messenger RNA as well as GANP protein in B220-positive B cells in vitro. GANP is a 210-kd protein localized in both the cytoplasm and nuclei, with a homologous region to Map80 that is associated with MCM3, a protein essential for DNA replication. Remarkably, GANP is associated with MCM3 in B cells and MCM3 is also up-regulated in the GC area. These results suggest that the up-regulation of GANP might participate in the development of Ag-driven B cells in GCs through its interaction with MCM3. | lld:uniprot |
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http://purl.uniprot.org/cit... | uniprot:name | Blood | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kimura H. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Watanabe Y. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Yoshida M. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tokuhisa T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Sakata A. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kouno Y. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Fujimura S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Abe E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Sakaguchi N. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kondo E. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Kuwahara K. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Ezaki T. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:author | Tomiyasu S. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:date | 2000 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:pages | 2321-2328 | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:title | A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. | lld:uniprot |
http://purl.uniprot.org/cit... | uniprot:volume | 95 | lld:uniprot |
uniprot-protein:Q9WUU9 | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
http://purl.uniprot.org/emb... | uniprot:citation | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | uniprot:source | http://purl.uniprot.org/cit... | lld:uniprot |
http://linkedlifedata.com/r... | rdf:object | http://purl.uniprot.org/cit... | lld:uniprot |