F31AA7D992C200118C3A73ECF7A7BFFD85CD5A3BED28D0569CD9CEF69E04035C30B30BA5A68822E78BD39F9ABF8C07F9

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with ARNTL is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Binds weakly ARNTL and ARNTL2 to form heterodimers which bind poorly to the E-box motif (By similarity).

Source:http://purl.uniprot.org/SHA-384/F31AA7D992C200118C3A73ECF7A7BFFD85CD5A3BED28D0569CD9CEF69E04035C30B30BA5A68822E78BD39F9ABF8C07F9