AE1A48D09EFA260DEBFB14753F5A24AC4163248DECAC0FE12A27C3C606560E617AD0A0358CBE65E05812CE60F5A25299

Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles. NSP4 also localizes in vesicular structures, which contain an autophagosomal marker and associate with viroplasms in virus-infected cells (By similarity).

Source:http://purl.uniprot.org/SHA-384/AE1A48D09EFA260DEBFB14753F5A24AC4163248DECAC0FE12A27C3C606560E617AD0A0358CBE65E05812CE60F5A25299