57275B55D1745FFC321A7225982BCA1850191148E5C9944B983F7E6E90C3E6A21AF51A66E7CB91EF327F1261ADC5D053

Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles. NSP4 also localizes in vesicular structures, which contain an autophagosomal marker and associate with viroplasms in virus-infected cells (By similarity).

Source:http://purl.uniprot.org/SHA-384/57275B55D1745FFC321A7225982BCA1850191148E5C9944B983F7E6E90C3E6A21AF51A66E7CB91EF327F1261ADC5D053