Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
| Subject | Predicate | Object | Context |
|---|---|---|---|
| http://purl.uniprot.org/SHA... | rdf:type | uniprot:PTM_Annotation | lld:uniprot |
| http://purl.uniprot.org/SHA... | rdfs:comment | Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity). | lld:uniprot |
| uniprot-protein:Q5UEM8 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q5UEM7 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q8TEY5 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |