Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity).
| Subject | Predicate | Object | Context |
|---|---|---|---|
| http://purl.uniprot.org/SHA... | rdf:type | uniprot:Function_Annotation | lld:uniprot |
| http://purl.uniprot.org/SHA... | rdfs:comment | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity). | lld:uniprot |
| uniprot-protein:Q75DB8 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q59LR2 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q6FX42 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q8SSE7 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:Q6CT34 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| http://linkedlifedata.com/r... | rdf:subject | http://purl.uniprot.org/SHA... | lld:uniprot |