Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity).
| Subject | Predicate | Object | Context |
|---|---|---|---|
| http://purl.uniprot.org/SHA... | rdf:type | uniprot:PTM_Annotation | lld:uniprot |
| http://purl.uniprot.org/SHA... | rdfs:comment | Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity). | lld:uniprot |
| uniprot-protein:Q1JQA2 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:P70340 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
| uniprot-protein:P97588 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |