| family:PF01429.14 | rdf:type | pfam:Family | lld:pfam |
| family:PF01429.14 | family:comment | The Methyl-CpG binding domain (MBD) binds to DNA that containsone or more symmetrically methylated CpGs [1]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [1]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [2]. | lld:pfam |
| family:PF01429.14 | family:id | MBD | lld:pfam |
| family:PF01429.14 | family:description | Methyl-CpG binding domain | lld:pfam |
| family:PF01429.14 | family:authorList | Bateman A | lld:pfam |
| family:PF01429.14 | family:familyType | Domain | lld:pfam |
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| family:PF01429.14 | family:pubmed | pubmed-article:10050851 | lld:pfam |
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