| http://linkedlifedata.com/r... | rdf:type | entrezgene:HIVInteraction | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:22190034 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19275588 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20012529 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18514189 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19275579 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20347598 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19798433 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20008788 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18541215 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19458171 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19674438 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17360488 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17855541 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19275585 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20870715 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:22292079 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17609381 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17626091 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17630831 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18606781 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19667756 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20069611 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20089662 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20380700 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18524771 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21957298 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:22438978 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:interactant | entrez-gene:1642 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr interacts with damage-specific DNA-binding protein 1 (DDB1) in cells. L64P mutation in DDB1 fails to interact efficiently with Vpr | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr interferes with the interaction of DDB1 and DDB2 in cells | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr binds a ternary complex composed of DDB1, DDA1, and VprBP, and modulates the interaction between the DDB1-DDA1-VprBP complex and other factors | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr binds the Cul4A-DDB1-VprBP complex and increases the levels of neddylated Cul4A in that complex only | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | The interaction between Vpr and the Cul4A-DDB1-VprBP complex is required for the induction of G2 arrest | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr(Q65R) mutant, which is defective in Cul4A-DDB1 (DCAF1) binding, undergoes proteasome-mediated degradation at a higher rate than wild-type Vpr. DCAF1 overexpression stabilizes wild-type Vpr and leads to its cytoplasmic accumulation | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | DDB1 overexpression enables G2 cell cycle arrest by both HIV-1 Vpr and its carboxy-terminally truncated form C81 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | DCAF1 interacts with DDB1 as well as the Vpr-UNG2 complex, which leads to polyubiquitination of UNG2 via Vpr | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:geneRifText | HIV-1 Vpr significantly downregulates expression level of MFN2 in the mitochondria via VprBP-DDB1-CUL4A ubiquitin ligase in a proteasome-dependent manner | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | inhibits | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | interacts with | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | cooperates with | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | binds | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | stabilized by | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:keyphrase | induces complex with | lld:entrezgene |
| entrez-gene:155807 | entrezgene:hivInteraction | http://linkedlifedata.com/r... | lld:entrezgene |
