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http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21110817 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17982468 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18005716 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18321968 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:interactant | entrez-gene:7251 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | Expression of HIV-1 Gag attenuates SDF-1-mediated downregulation of CXCR4. The effect of Gag is dependent on a TSG101 interacting motif within the C-terminal p6 region of Gag | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The direct binding of the UEV domain (amino acids 1-145) of TSG101 to the L domain (amino acids 7-10) of HIV-1 p6-Gag is essential for the p6 directed budding of HIV-1 virions from infected cells | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The p6 domain of HIV-1 Gag mimics the Tsg101-recruiting activity of the human Hrs protein | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | AIP1 binds to the LXXLF motif in HIV-1 p6 (amino acids 41-44) and also binds to TSG101 to act as a component of the viral budding machinery | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | Tsg 101, VPS 28, and VPS 37B form the human endosomal sorting complex required for transport (ESCRT-I), which is required for HIV-1 Gag budding and virus infectivity | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | Tal, a Tsg101-associated ligase, binds and ubiquitylates Tsg101; Tal-mediated binding and ubiquitylation of Tsg101 cooperatively regulate release of HIV-1 Gag | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The PTAP sequence (179-182) in the GAT domain and the PSAP sequence (310-313) in the C-terminal region of Tom1L1 are required for its interaction with the UEV domain (1-145) of Tsg101 and competes with HIV-1 Gag | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | A genetically selected cyclic peptide IYWNVSGW inhibits HIV budding by targeting the interaction between the p6 domain of Gag and TSG101. The inhibitory activity of the peptide is PT/SAP dependent | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The Bro1 domain of Alix inhibits HIV budding by targeting both PTAP/TSG101 and LYPXnL/Alix pathways. The NC domain of Gag is the primary target for Bro1 inhibition by Gag-mediated recruitment of Bro1 to the plasma membrane | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The p1 spacer peptide in HIV-1 Gag can confer a requirement for Tsg101 binding. Removal of NC-p1 region from authentic HIV-1 alleviates sensitivity to dominant-negative CHMP3 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The hydroxyl of the Thr or Ser residue in the P(S/T)AP motif of HIV-1 Gag forms hydrogen bonds with the main chain of Asn69. Mutation of the Asn to Pro abrogates PTAP motif binding to TSG101 and blocks budding of HIV-1 from cells | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | TSG101 binding to HIV-1 Gag correlates with redistribution of IP3R to the plasma membrane | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | A short helix (helix-1; amino acid residues 14-18) in HIV-1 p6 enhances the binding of the p6 PTAP motif (residues 7-10) to TSG101 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | Expression of HIV-1 Gag attenuates SDF-1-mediated downregulation of CXCR4. This effect of Gag is dependent on a TSG101 interacting motif within the C-terminal p6 region of Gag | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | NEDD4L-mediated stimulation of virus budding is dependent upon the ubiquitin ligase activity of NEDD4L and requires only the minimal HIV-1 Gag assembly regions and TSG101 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | Employing N-alkylglycine ('peptoid') residues to the p6-derived 9-mer sequence 'PEPTAPPEE' improves peptide binding affinity to the ubiquitin E2 variant domain of TSG101 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:geneRifText | The hydroxyl of the Thr or Ser residue in the P(S/T)AP motif of HIV-1 p6 forms hydrogen bonds with the main chain of Asn69. Mutation of the Asn to Pro abrogates PTAP motif binding to TSG101 and blocks budding of HIV-1 from cells | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:keyphrase | interacts with | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:keyphrase | regulated by | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:keyphrase | binds | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:keyphrase | recruits | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:keyphrase | complexes with | lld:entrezgene |
entrez-gene:155030 | entrezgene:hivInteraction | http://linkedlifedata.com/r... | lld:entrezgene |