Linked Life Data

Q9WVS8

Source:http://identifiers.org/uniprot/Q9WVS8

Statements in which the resource exists.
SubjectPredicateObjectContext
http://identifiers.org/unip...rdf:typebiopax3:ProteinReferencelld:biopax3
http://identifiers.org/unip...biopax3:commentSEQUENCE 806 AA; 87733 MW; E7CC41C4BBDE0633 CRC64;lld:biopax3
http://identifiers.org/unip...biopax3:commentFUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by tyrosine and threonine phosphorylation. Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF) (By similarity). SUBUNIT: Interacts with MAP2K5 (By similarity). Forms oligomers. Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm (By similarity). Nucleus (By similarity). Note=Isoform 1 is detected in cytoplasm and nucleus (By similarity). SUBCELLULAR LOCATION: Isoform 2: Nucleus (By similarity). Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). SUBCELLULAR LOCATION: Isoform 3: Nucleus (By similarity). Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Big MAP kinase 1a, mERK5a; IsoId=Q9WVS8-1; Sequence=Displayed; Name=2; Synonyms=Big MAP kinase 1b, mERK5b; IsoId=Q9WVS8-2; Sequence=VSP_035202; Note=May not have a kinase activity. May not stimulate MEF2C activity. May function as dominant negative inhibitor of the ERK5 signaling pathway; Name=3; Synonyms=Big MAP kinase 1c, mERK5c; IsoId=Q9WVS8-3; Sequence=VSP_035201; Note=May not have a kinase activity. May not stimulate MEF2C activity. May function as dominant negative inhibitor of the ERK5 signaling pathway; Name=4; Synonyms=Big MAP kinase 1d, mERK5-T; IsoId=Q9WVS8-4; Sequence=VSP_035203; Note=Unable to translocate from the cytoplasm to the nucleus; Name=5; IsoId=Q9WVS8-5; Sequence=VSP_035204; Note=No experimental confirmation available; TISSUE SPECIFICITY: Detected in testis, brain, kidney, lung and heart. Detected in total embryo (at protein level). DOMAIN: The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS:Mapk7 Bmk1 Erk5. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biopax3
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http://identifiers.org/unip...biopax3:displayNameMK07_MOUSElld:biopax3
http://identifiers.org/unip...biopax3:name2.7.11.24lld:biopax3
http://identifiers.org/unip...biopax3:nameMapk7lld:biopax3
http://identifiers.org/unip...biopax3:nameMAP kinase 7lld:biopax3
http://identifiers.org/unip...biopax3:nameBMK-1lld:biopax3
http://identifiers.org/unip...biopax3:nameExtracellular signal-regulated kinase 5lld:biopax3
http://identifiers.org/unip...biopax3:nameBig MAP kinase 1lld:biopax3
http://identifiers.org/unip...biopax3:nameERK-5lld:biopax3
http://identifiers.org/unip...biopax3:nameMAPK 7lld:biopax3
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http://identifiers.org/unip...biopax3:organismhttp://identifiers.org/taxo...lld:biopax3
http://identifiers.org/unip...biopax3:sequenceMAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEPlld:biopax3
http://identifiers.org/unip...biopax3:standardNameMitogen-activated protein kinase 7lld:biopax3
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http://www.pantherdb.org/pa...biopax3:memberEntityReferen...http://identifiers.org/unip...lld:biopax3