| http://biocyc.org/biopax/bi... | rdf:type | biopax3:Protein | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:comment | There are three isoforms of 1-D-myo-inositol-1,4,5-trisphosphate 3-kinase in mammals. The three isoforms differ in their N-terminal sequence, sensitivity to Ca2+/calmodulin and molecular mass |CITS: [11846419]|. All three isozymes help to regulate inositol phosphate metabolism by phosphorylation of the second messenger |FRAME: INOSITOL-1-4-5-TRISPHOSPHATE| to form |FRAME: CPD-506|. This activity is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. A cDNA encoding |FRAME: HS06405-MONOMER| was isolated from human brain |CITS: [2175886]| and expressed in E. coli in a truncated form |CITS: [1847047]|. Biochemical characterization revealed three active fractions with apparent molecular weight of 580-64 kDa, 45-50 kDa and 3-39 kDa |CITS: [1847047]|. The author speculate that the higher molecular weight form may have been an isozyme (the two isozymes |FRAME: HS07103-MONOMER| and |FRAME: HS01533-MONOMER| are both larger), while the smaller form probably represented a degradation product. The enzyme is subject to both calcium/calmodulin and protein phosphorylation regulation |CITS: [2176078][1847047]|. Studies with the rat enzyme found that it is a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C <i>in vitro</i> |CITS: [9374536]|. The |FRAME: HS06405| gene has been localized to chromosome region 15q14-q21 |CITS: [1330886 ]|. | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:dataSource | urn:biopax:Provenance:human... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:dataSource | http://biocyc.org/biopax/bi... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:displayName | IP3K | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | IP3 3-kinase | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | 1-D-myo-inositol-trisphosphate 3-kinase A | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | 1-D-myo-inositol-1,4,5-trisphosphate 3-kinase A | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:name | inositol 1,4,5-trisphosphate 3-kinase A | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:entityReference | http://identifiers.org/unip... | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:standardName | inositol-trisphosphate 3-kinase A | lld:biopax3 |
| http://biocyc.org/biopax/bi... | biopax3:controller | http://biocyc.org/biopax/bi... | lld:biopax3 |
