| umls-concept:C1706121 | skos:definition | NCI: Human CYP3A5*10 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*10 protein. This allele exhibits a clinically-relevant SNP (g.6986A>G) in exon 10 that causes a splicing defect. The resulting alteration in protein sequence almost completely abolishes the enzymatic activity of the cytochrome P450 3A5*10 protein. | lld:umls |
