| umls-concept:C1514422 | skos:definition | NCI: A glioblastoma arising de novo, with no prior evidence of lower grade astrocytoma. It occurs mostly in older patients and is associated with specific molecular abnormalities, notably epidermal growth factor receptor (EGFR) overexpression and also mouse double minute 2 (MDM2) gene amplification. -- 2004 | lld:umls |
