| umls-concept:C1172734 | rdf:type | umls-semnetwork:T116 | lld:umls |
| umls-concept:C1172734 | rdf:type | umls-semnetwork:T121 | lld:umls |
| umls-concept:C1172734 | rdf:type | umls-semnetwork:T129 | lld:umls |
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| umls-concept:C1172734 | calbc:hasCorrelation | calbc-group:DISO | lld:calbc |
| umls-concept:C1172734 | calbc:hasCorrelation | calbc-group:PHYS | lld:calbc |
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| umls-concept:C1172734 | calbc:hasCorrelation | calbc-group:CHEM | lld:calbc |
| umls-concept:C1172734 | skos:definition | NCI: A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with immunomodulating, anti-inflammatory, and potential antineoplastic activities. Natalizumab binds to the alpha4-subunit of alpha4beta1 and alpha4beta7 integrins expressed on the surface of all leukocytes except neutrophils, inhibiting the alpha4-mediated adhesion of leukocytes to counter-receptor(s) such as vascular cell adhesion molecule-1 (VCAM-1); natalizumab-mediated disruption of VCAM-1 binding by these integrins may prevent the transmigration of leukocytes across the endothelium into inflamed parenchymal tissue. Integrins are cellular adhesion molecules (CAMs) that are upregulated in various types of cancer and some autoimmune diseases; alpha4beta1 integrin (VLA4) has been implicated in the survival of myeloma cells, possibly by mediating their adhesion to stromal cells. | lld:umls |
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| umls-concept:C1172734 | skos:narrower | umls-concept:C1173150 | lld:umls |
| umls-concept:C1172734 | skos:narrower | umls-concept:C1529600 | lld:umls |
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| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A10653512 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A15537050 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A18056218 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A18681697 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A9437315 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A9437316 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A16769365 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A18245271 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A8482500 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A16755830 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A17912327 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A17936325 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A8452294 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A17936326 | lld:umls |
| umls-concept:C1172734 | skos-xl:altLabel | umls-label:A17679238 | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C1172734 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
