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| umls-concept:C0935916 | skos:definition | NCI: A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen.,PDQ: A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43053&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43053&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Th | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
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| umls-concept:C0935916 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
