| umls-concept:C0246330 | rdf:type | umls-semnetwork:T109 | lld:umls |
| umls-concept:C0246330 | rdf:type | umls-semnetwork:T121 | lld:umls |
| umls-concept:C0246330 | rdf:type | skos:Concept | lld:umls |
| umls-concept:C0246330 | calbc:hasCorrelation | calbc-group:DISO | lld:calbc |
| umls-concept:C0246330 | calbc:hasCorrelation | calbc-group:PHYS | lld:calbc |
| umls-concept:C0246330 | calbc:hasCorrelation | calbc-group:CONC | lld:calbc |
| umls-concept:C0246330 | calbc:hasCorrelation | calbc-group:CHEM | lld:calbc |
| umls-concept:C0246330 | skos:definition | NCI: A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa. | lld:umls |
| umls-concept:C0246330 | skos:inScheme | lld:umls | lld:umls |
| umls-concept:C0246330 | skos:broader | umls-concept:C0003405 | lld:umls |
| umls-concept:C0246330 | skos:broader | umls-concept:C0005077 | lld:umls |
| umls-concept:C0246330 | skos:broader | umls-concept:C0014432 | lld:umls |
| umls-concept:C0246330 | skos:broader | umls-concept:C0028188 | lld:umls |
| umls-concept:C0246330 | skos:narrower | umls-concept:C0084396 | lld:umls |
| umls-concept:C0246330 | skos:narrower | umls-concept:C0595276 | lld:umls |
| umls-concept:C0246330 | skos-xl:prefLabel | umls-label:A0490607 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A0490605 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A0490606 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A10338321 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A17882645 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A10770432 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A8482349 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A18503832 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A10773106 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A17906793 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A17906794 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A8438290 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A17954890 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A0147073 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A10810692 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A10801023 | lld:umls |
| umls-concept:C0246330 | skos-xl:altLabel | umls-label:A18026597 | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
| umls-concept:C0246330 | umls:relation | http://linkedlifedata.com/r... | lld:umls |
