| umls-concept:C0136123 | skos:definition | MSH: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.,NCI: A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. | lld:umls |
