| umls-concept:C0073393 | skos:definition | CSP: selective blocker of dopamine D2 and serotonin-5-HT2 receptors that acts as an atypical antipsychotic agent; has been shown to improve both positive and negative symptoms in the treatment of schizophrenia.,MSH: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.,CHV: a drug used to treat the symptoms of schizophrenia,NCI: A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors. | lld:umls |
