| umls-concept:C0041348 | skos:definition | MSH: A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.,CSP: globular subunit of microtubules, whose ATP- and GTP-dependent polymerization and depolymerization is the basis for many intracellular movement functions.,NCI: One of a group of proteins found in high levels in the cell cytoplasm (fluid inside a cell but outside the cell's nucleus). Tubulins are the building blocks of microtubules (narrow, hollow tubes inside a cell), which are involved in cell division and cell movement. Certain anticancer drugs bind to and block the formation or function of tubulins, which may block cell division.,NCI: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tub | lld:umls |
