| umls-concept:C0039902 | skos:definition | MSH: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.,CSP: thioguanine is USP.,NCI: An anticancer drug that belongs to the family of drugs called antimetabolites.,CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,PDQ: A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C876" NCI The | lld:umls |
