| umls-concept:C0027540 | skos:definition | MSH: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.,CSP: sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.,NCI: Refers to the death of tissues.,GO: A permanent cessation of all vital functions of a tissue. [GOC:dph],GO: OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. [GOC:ma],GO: A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. [PMID:18846107],NCI: A cell death process that is morphologically characterized by a gain in cell volume (oncosis), | lld:umls |
