| umls-concept:C0025147 | skos:definition | MSH: (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.,CSP: synthetic progestin derived from 17-hydroxyprogesterone; a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.,NCI: A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.,PDQ: A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39813&idtype=1" active clinical trials or "http://www.can | lld:umls |
