| umls-concept:C0021760 | skos:definition | MSH: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.,CSP: cytokine produced by antigen or mitogen activated T lymphocytes, fibroblasts and macrophages that serves as a differentiation factor for lymphocytes and stimulates immunoglobulin production by B lymphocytes; it also innitiates the cell cycle in primitive hematopoietic cells in vitro.,NCI: Interleukin-6 (IL-6), a glycoprotein produced by activated T-cells and a variety of other cells, induces the production of IgM by B-cells and can be used to replace feeder cells for the growth and maintenance of B-cell hybridomas in vitro.,NCI: Produced by T-cells, monocytes, fibroblasts, and many other cells, Interleukin 6 stimulates the growth of hybridomas and plasmacytomas, as well as the growth and differentiation of B-cells. Il6 increases synthesis and secretion of immunoglobulins by | lld:umls |
