| umls-concept:C0020811 | skos:definition | MSH: An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.,CSP: pyrimidine analog which inhibits viral DNA synthesis.,NCI: A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.,PDQ: An iodinated analogue of deoxyuridine. Idoxuridine incorporates into DNA during the S-phase of the cell cycle, sensitizing cells to ionizing radiation by increasing DNA strand breaks. When this agent contains a radioactive isomer of iodine, the radioactive idoxuridine kills cancer cells directly after preferential incorporation into the DNA of rapidly dividing tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39481&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39481&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C563" NCI Thesaurus),NCI: An iodinated analog of deoxyuridine | lld:umls |
