| umls-concept:C0015846 | skos:definition | MSH: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078),CSP: potent narcotic analgesic, abuse of which leads to habituation or addiction; primarily a mu-opioid agonist, used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance.,CHV: a kind of narcotic pain relieving drug,CHV: a kind of narcotic pain relieving drug,CHV: a kind of narcotic pain relieving drug,NCI: A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. | lld:umls |
